TABLE 3.
Resuscitation care from baseline to 72 hours, stratified by receipt of initial EMS care.
| Characteristic | EMS Care (n=826) |
No EMS Care (n=515) |
Odds Ratio (95% CI) and P-values |
|---|---|---|---|
| Trial Randomization | |||
| Time from arrival to randomization (mins) | 177.1 (98.7) | 204.3 (121.4) | P<0.001 |
| Time eligibility to randomization (mins) | 68.3 (37.5) | 69.2 (76.7) | P=0.77 |
| Trial Intervention Arm | |||
| Early Goal Directed Therapy | 266 (32.2) | 173 (33.6) | 1.03 (0.79-1.35) |
| Protocolized Standard Care | 287 (34.7) | 159 (30.9) | 1.21 (0.92-1.58) |
| Usual Care | 273 (33.1) | 183 (35.5) | Ref |
| Randomization to Hour 6 | |||
| Intravenous fluids (ml) | 2,827±1,872 | 2,719±1,960 | P=0.31 |
| Vasopressor use | 444 (53.8) | 231 (44.8) | 1.43 (1.14-1.78) |
| Dobutamine Use | 28 (3.4) | 16 (3.1) | 1.09 (0.59-2.04) |
| Blood Transfusion | 89 (10.8) | 45 (8.7) | 1.26 (0.86-1.84) |
| Mechanical Ventilation | 263 (31.8) | 62 (12.0) | 3.41 (2.52-4.62) |
| Hours 6-72 | |||
| Intravenous fluids (ml) | 4,628±4,096 | 4,491±3,930 | P=0.54 |
| Vasopressor use | 391 (47.3) | 223 (43.3) | 1.18 (0.94-1.47) |
| Dobutamine Use | 25 (3.0) | 13 (2.5) | 1.20 (0.61-2.38) |
| Blood Transfusion | 172 (20.8) | 90 (17.5) | 1.24 (0.94-1.65) |
| Mechanical Ventilation | 305 (36.9) | 110 (21.4) | 2.16 (1.67-2.78) |
| Ancillary Care | |||
| Central Venous Catheterization | 591 (71.6) | 336 (65.2) | 1.34 (1.06-1.70) |
| Central Venous Oximeter Catheterization | 266 (32.2) | 177 (34.4) | 0.91 (0.72-1.14) |
| Intravenous Antibiotics | 803 (97.2) | 500 (97.1) | 1.05 (0.54-2.03) |
| Corticosteroids | 96 (11.6) | 43 (8.3) | 1.44 (0.99-2.11) |
| Activated Protein C | 1 (0.1) | 1 (0.2) | 0.62 (0.04-9.98) |