Table 2.
Glucose control and gestational weight gain in women with type 1 diabetes during pregnancy over 14 years of follow-up.
| 2004–2008 n = 214 | 2009–2012 n = 215 | 2013–2017 n = 271 | P for trend | |
|---|---|---|---|---|
| aHbA1c % 1st trimester (n = 636) | 7.01 ± 1.31 | 6.88 ± 1.14 | 6.98 ± 1.05 | P = 0.83 |
| HbA1c mmol/mol 1st trimester (n = 636) | 53 ± 9.89 | 52 ± 8.6 | 53 ± 8 | P = 0.83 |
| bHbA1c < 6.5% 1st trimester (n = 636) | 72 (37.3%) | 72 (37.9%) | 84 (33.2%) | P = 0.35 |
| aHbA1c % 2nd trimester (n = 660) | 6.37 ± 0.94 | 6.24 ± 0.79 | 6.26 ± 0.74 | P = 0.20 |
| HbA1c mmol/mol 2nd trimester (n = 660) | 46 ± 6.8 | 45 ± 6.3 | 45 ± 6 | P = 0.20 |
| bHbA1c < 6.0% 2nd trimester (n = 660) | 70 (34.0%) | 77 (38.5%) | 87 (34.3%) | P = 1.00 |
| aHbA1c % 3rd trimester (n = 648) | 6.38 ± 0.79 | 6.31 ± 0.81 | 6.29 ± 0.68 | P = 0.18 |
| HbA1c mmol/mol 3rd trimester (n = 648) | 46 ± 5.6 | 45 ± 5.8 | 45 ± 5 | P = 0.18 |
| bHbA1c < 6.0% 3rd trimester (n = 648) | 60 (29.6%) | 59 (31.1%) | 76 (29.8%) | P = 0.97 |
| Gestational weight gain (lbs.) (n = 585) | 20.38 ± 10.33 | 19.11 ± 9.34 | 21.31 ± 10.91 | P = 0.28 |
| Excessive weight gain during pregnancy (n = 527) | 23, 16.3% | 23, 15.4% | 62, 26.2% | P = 0.01 |
Data are means ± SD or n (%). P values were calculated for trend.
aMaternal HbA1c data were available for N = 636 in the first trimester, N = 660 in the second trimester, and N = 648 in the third trimester.
bTarget HbA1c value were <6.5% (48 mmol/mol) in the first trimester and <6.0% (42 mmol/mol) in the second and third trimester. Numbers may not sum up to 700 due to missing data on glucose control and weight gain measures.