Fig. 1.

Treatment escalation according to clinical and inflammatory status.

DAMP, damage associated molecular pattern; PAMP, pathogen associated molecular pattern; ICU, intensive care unit; SMT, standard medical therapy; EOL, end of life; MODS, multiple organ dysfunction syndrome. Blue boxes indicate the progress, white boxes the possible interventions. For further explanation please see text. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)