Author Correction: Nuclear-mitochondrial DNA segments resemble paternally inherited mitochondrial DNA in humans

Correction to: Nature Communications 10.1038/s41467-020-15336-3, published online 8 April 2020.

The original version of this Article contained an error in an equation in the Methods in the section “Estimating the number of mtDNA fragments within each NUMT”. The equation for calculating the number of mtDNA fragments within each nuclear-mitochondrial DNA segment and its explanation incorrectly read:

The number of copies of mtDNA-derived fragments (Nmt) within the same NUMT was estimated as:

$$\mathrm{Nmt}=\frac{\mathrm{DPnumt}÷2}{\mathrm{DPnumt}÷2+\mathrm{Altmt}}$$

where DPnumt is the average depth of the NUMT sequence surrounding region where discordant reads aligned on the nuclear genome; and Altmt is the number of reads supported alternative allele from the informative variants within the mixed haplotype. If the AF > 50%, Altmt = DPmt – Altmt’. DPmt is the depth of the informative variant, Altmt’ is the initial number of reads supported alternative allele.

The correct version of this paragraph is:

The number of copies of mtDNA-derived fragments (Nmt) within the same NUMT was estimated as:

$$Nmt=\frac{Altmt}{DPadjnumt÷2}$$

where DPadjnumt is the average depth of the nuclear genome sequencing flanking the NUMT (derived from both complementary chromosomes); and Altmt is the number of reads supporting the alternative allele from the informative variants within the mixed haplotype. If the AF > 50%, Altmt = DPmtvar – Altmt’. DPmtvar is the depth of the informative variant, Altmt’ is the initial number of reads supported alternative allele.

We confirm that the correct equation was used in our analyses, and that this correction does not change our results.

This has now been corrected in the PDF and HTML versions of the Article.