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. 2020 Jul 22;10:12209. doi: 10.1038/s41598-020-68115-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Region-specific distribution of thalamic inputs to cortical CRH neurons. (A) The front 3D view of input neurons in thalamus. (B) The planform 3D view of input neurons in thalamus. (C) The lateral 3D view of input neurons in thalamus. The top one is the over view of afferent neurons input to CRH neurons in different cortical areas. The six below are input neurons to mPFC, M1, S2, S1BF, Au and V1, respectively. (D) The monosynaptic relationship and intensity between the thalamic nuclei and cortical CRH neurons. Polylines in different color represent the input to different cortical CRH cortex, and the thick arrows indicate dense distribution of input neurons. (E) The diagram of connection between cortical CRH neurons and thalamus. (A,B,C,E) 3D vision displayed via Amira software (v5.2.2, Mercury Computer Systems, San Diego, CA, United States).The abbreviations of brain regions are provided in Supplementary Table S2.