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. 2020 Jul 22;11:3677. doi: 10.1038/s41467-020-17135-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a IHC staining of the FDC marker CD35 (green) and CXCL13 (red) in human lymph nodes and tonsils. b The spatial autocorrelation of CXCL13 expression in samples from one patient, each line represents the spatial autocorrelation for a distinct follicle. c Comparison of the distances at which no statistically significant spatial autocorrelation (determined using permutation testing as described in “Methods”) was detected in human tonsils, and for models 1 and 2. Each data point represents the distance at which no statistically significant spatial autocorrelation was observed for the intensity of anti-CXCL13 staining in a distinct tonsil follicle, with data pooled from five different patients. The red line represents the median distance for each group with significance, the human dataset and each simulation model (run with 200 repeat executions) assessed using the Mann−Whitney U test (p value = 0.06 for model 1 and p < 0.001 (denoted as *) for model 2). Source data are provided as a Source Data file.