Table 3.
Comparison of plasma cytokines after six ketamine infusions using linear mixed-model analysis.
| Variables | F | p | Day 13 vs day 0 | Day 26 vs day 0 | ||
|---|---|---|---|---|---|---|
| t | p | t | p | |||
| MADRS | 111.313 | <0.001 | 12.821 | <0.001 | 12.802 | <0.001 |
| ITAC | 1.430 | 4.617 | −1.186 | 0.725 | 0.438 | 1.000 |
| GM-CSF | 6.123 | 0.007 | −0.389 | 1.000 | 2.857 | 0.025 |
| Fractalkine | 13.211 | <0.001 | 0.138 | 1.000 | 4.517 | <0.001 |
| IFN-γ | 7.759 | 0.001 | 0 | 1.000 | 3.375 | 0.005 |
| IL-10 | 7.475 | 0.001 | −0.091 | 1.000 | 3.364 | 0.005 |
| MIP-3α | 6.111 | 0.007 | −0.683 | 1.000 | 2.634 | 0.052 |
| IL-12p70 | 8.557 | 0.001 | −0.333 | 1.000 | 3.133 | 0.011 |
| IL-13 | 2.341 | 0.855 | 0.657 | 1.000 | 2.171 | 0.182 |
| IL-17A | 10.325 | <0.001 | −0.375 | 1.000 | 3.688 | 0.002 |
| IL-1β | 5.841 | 0.007 | −0.229 | 1.000 | 2.886 | 0.028 |
| IL-2 | 7.467 | 0.001 | 0.273 | 1.000 | 3.424 | 0.004 |
| IL-4 | 4.034 | 0.095 | 0.700 | 1.000 | 2.800 | 0.044 |
| IL-23 | 5.813 | 0.007 | −0.048 | 1.000 | 2.977 | 0.022 |
| IL-5 | 6.993 | 0.001 | −0.282 | 1.000 | 3.128 | 0.016 |
| IL-6 | 6.157 | 0.007 | 0.933 | 1.000 | 3.378 | 0.007 |
| IL-7 | 8.438 | <0.001 | −0.152 | 1.000 | 3.485 | 0.005 |
| IL-8 | 4.941 | 0.034 | −1.571 | 0.482 | 1.543 | 0.992 |
| MIP-1β | 2.819 | 0.526 | 1.250 | 0.956 | 2.292 | 0.214 |
| TNF-α | 9.89 | <0.001 | 0.385 | 1.000 | 4.000 | <0.001 |
ITAC interferon-inducible T cell alpha chemoattractant, GM-CSF granulocyte macrophage colony-stimulating factor, IFN-γ interferon gamma, IL interleukin, MIP macrophage inflammatory protein, TNF-α tumor necrosis factor alpha, MADRS Montgomery–Asberg Depression Rating Scale.
Bolded values are p < 0.05.