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. 2020 Jun 17;119(2):360–374. doi: 10.1016/j.bpj.2020.06.010

Figure 7.

Figure 7

Normal mode analysis of MMP1 using the ANM. Three-dimensional scatter plots of S142–S366 distance (represents interdomain dynamics), N171–T230 distance (represents the opening of the MMP1 catalytic pocket), and rms distance between the MMP1 catalytic site and the cleavage sites on three collagen chains for (A) collagen-bound activated (green) and (B) pro (greenish-yellow) MMP1. Two-dimensional projections in (A) and (B) of the scatter plots are in gray. Two-dimensional scatter plots of S142–S366 distance and N171–T230 distance for free (C) activated (green) and (D) pro (greenish-yellow) MMP1. To see this figure in color, go online.