Figure 8.

Interdomain communications via collagen even without the linker. The catalytic pocket openings as measured by the distance between N171 and T230 (cyan line) are (A) 2.56 ± 0.52, (B) 2.56 ± 0.26, and (C) 2.55 ± 0.19 nm. The error bars represent the SDs of 60 measurements of the catalytic pocket opening obtained from 20 frames each for the three slowest normal modes. The red, blue, and green spheres on collagen represent the cleavage sites. The catalytic domain (cyan), the linker (brown), and the hemopexin (wheat) domains represent the residue ranges F100–Y260, G261–C278, and D279–C466, respectively. To see this figure in color, go online.