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. 2020 Jul 22;10:12133. doi: 10.1038/s41598-020-69193-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Cycle-length dependent APD₉₀ under baseline conditions (filled rhombus) and after treatment with 50 µM (filled square), 75 µM (filled traingle) or 100 µM (filled circle) propofol. (b) Impact of propofol on effective refractory periods (ERP). (c) Concentration-dependent effect of propofol on post-repolarization refractoriness (^#p < 0.05 compared to baseline conditions). (d) Box plots of the ratio of action potential duration at 90% of repolarization (APD₉₀) and action potential duration at 50% of repolarization (APD₅₀). A decrease in APD₉₀/APD₅₀ represents a rectangulation of action potential. (e) Influence of propofol treatment on repolarization heterogeneity as indicated by spatial dispersion of repolarization (^#p < 0.05 compared to baseline conditions). (f) Occurrence of ventricular fibrillation (VF) tachycardia (VT) induced by programmed ventricular fibrillation.