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. 2020 Jul 22;10:12133. doi: 10.1038/s41598-020-69193-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a,b) Cycle-length dependent APD₉₀ and QT interval under baseline conditions (filled rhombus), after treatment with 5 µM ondansetron (filled square) and after additional infusion of 75 µM propofol (filled triangle). (c) Box plots of the ratio of APD₉₀ to APD₅₀ (^#p < 0.05 compared to baseline conditions) (d) Influence of ondansetron and propofol on spatial dispersion of repolarization (^#p < 0.05 compared to baseline conditions; *p < 0.05 compared to sole ondansetron administration). (e) Occurrence of torsade de pointes under baseline conditions, with ondansetron and with the combination of ondansetron and propofol (^#p < 0.05 compared to baseline conditions; *p < 0.05 compared to sole ondansetron treatment).