Table 4.
Association of LTL with the risk of ALS or FTD in the European and Asian populations.
| Method | ALS-european | FTD-european | ALS-asian |
|---|---|---|---|
| OR (95% CI, p) | OR (95% CI, p) | OR (95% CI, p) | |
| IVW-random | 1.10 (0.92–1.32, 0.284) | 0.81 (0.44–1.48, 0.498) | 0.75 (0.53–1.07, 0.116) |
| IVW-fixed | 1.10 (0.93–1.31, 0.274) | 0.81 (0.44–1.48, 0.498) | 0.75 (0.53–1.07, 0.116) |
| MR-Egger | 1.02 (0.32–3.29, 0.964) | 0.40 (0.01–14.71, 0.516) | 0.61 (0.24–1.56, 0.241) |
| Weighted Median | 1.06 (0.85–1.32, 0.624) | 0.73 (0.35–1.52, 0.400) | 0.67 (0.43–1.05, 0.082) |
| Likelihood | 1.10 (0.92–1.32, 0.290) | 0.81 (0.44–1.48, 0.496) | 0.75 (0.53–1.07, 0.115) |
| GSMR | 1.10 (0.93–1.31, 0.274) | 0.81 (0.44–1.48, 0.498) | 0.73 (0.51–1.05, 0.086)a |
The intercept of the MR-Egger regression is 0.006 (95% CI − 0.079–0.090, p = 0.872), 0.055 (95% CI − 0.214–0.323, p = 0.601) or 0.026 (95% CI − 0.076–0.128, p = 0.552), respectively.
aSeven instruments were finally employed because the genotype of rs41309367 on gene RTEL1 was missing in the 1,000 Genomes Project.