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. 2020 Jul 22;10:12181. doi: 10.1038/s41598-020-68899-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Feedback processing in the Placebo and in the LSD compared to the Placebo condition. Differences in BOLD signals for (A) HC > LC contrast for the feedback processing (FB) for Pla at peak in the mPFC voxel (x = − 3, y = 47, z = 25); (B) HC > NC FB contrast for Pla at peak SMA voxel (x = 6, y = 29, z = 52); (C) HC > LC FB contrast for Pla > LSD at peak mPFC voxel (peak: x = 0, y = 59, z = 19); (D) LC > NC FB contrast for LSD > Pla at peak mPFC voxel (peak: x = − 9, y = 62, z = 25); p < 0.05 FWE corrected (peak level after SVC). Red Shades represent an increase in BOLD signal. Blue shades represent an LSD-induced decrease in BOLD signal. Colorbars indicate t-values. Data displayed at p < 0.005, k > 10 (uncorrected). n = 24. (E) Comparison of Beta values in the mPFC for all conditions and treatments. Data are displayed as mean and standard error of the mean. *p < 0.05, Bonferroni corrected.