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. 2020 Jul 22;11:3662. doi: 10.1038/s41467-020-17033-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Formation of NP protein corona. Different NP physicochemical properties (indicated by three different colors) led to the formation of different protein corona compositions on the NP surface. b Proteograph platform workflow based on multi-NP protein corona approach and mass spectrometry for plasma proteome analysis. The Proteograph workflow includes four steps: (1) NP-plasma incubation and protein corona formation; (2) NP protein corona purification by a magnet; (3) digestion of corona proteins; and (4) LC-MS/MS analysis. In this context, each plasma-NP well is a sample, for a total of 96 samples per plate.