Table 3.
The association between DNA methylation (%) in the INSR and IGF2 and WC and BMI after adjusted for prenatal famine exposure, respectively.
| Gene loci | WC | BMI | ||
|---|---|---|---|---|
| Βeta (SE) | P | Βeta (SE) | P | |
| INSR | 17.29 (11.37) | 0.139 | 0.04 (2.80) | 0.989 |
| CpG 1 | 7.78 (7.31) | 0.289 | − 0.28 (1.84) | 0.878 |
| CpG 2 | 2.28 (7.74) | 0.769 | − 1.76 (2.05) | 0.391 |
| CpG 3 | 9.58 (7.93) | 0.229 | − 1.19 (1.94) | 0.541 |
| CpG 4 | 7.78 (7.31) | 0.289 | − 0.28 (1.84) | 0.878 |
| CpG 5 | 10.37 (6.25) | 0.099 | 0.77 (1.60) | 0.631 |
| CpG 6 | − 0.39 (5.95) | 0.948 | − 0.64 (1.45) | 0.657 |
| CpG 7 | 10.88 (4.62) | 0.020 | 1.56 (1.16) | 0.179 |
| CpG 8 | − 11.45 (31.58) | 0.718 | − 12.04 (8.60) | 0.164 |
| CpG 9 | 12.98 (12.99) | 0.332 | 9.63 (3.99) | 0.017 |
| IGF2 | − 10.04 (10.61) | 0.346 | − 1.01 (4.15) | 0.808 |
| CpG 1 | − 12.85 (6.73) | 0.062 | − 0.21 (2.37) | 0.930 |
| CpG 2 | − 0.67 (5.54) | 0.905 | 0.16 (2.17) | 0.942 |
| CpG 3 | 1.44 (6.32) | 0.819 | 1.70 (2.44) | 0.488 |
| CpG 4 | − 0.47 (6.71) | 0.944 | − 3.87 (2.62) | 0.143 |
| CpG 5 | − 81.03 (53.39) | 0.134 | − 12.22 (26.07) | 0.641 |
| CpG 6&7 | − 14.64 (12.34) | 0.238 | − 8.96 (5.01) | 0.076 |
| CpG 8 | − 6.40 (5.99) | 0.287 | − 1.59 (2.35) | 0.501 |
INSR insulin receptor gene, IGF2 insulin growth factor 2 gene, CI conference interval, WC waist circumference, BMI body mass index, SE standard error.
All the analysis adjusted for bisulfite batch, province, gender, physical activity level, the frequencies of meat, vegetables, fruit, milk, smoking and alcohol use.