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. 2020 Feb 18;34(8):1371–1379. doi: 10.1038/s41433-020-0809-0

Fig. 1. Schematic of aflibercept-loaded microsphere-hydrogel composite DDS.

Fig. 1

Aflibercept loaded PLGA microspheres are fabricated using Kang-Mieler modified double-emulsion, solvent evaporation technique. A poly(N-isopropylacrylamide) (PNIPAAm)-based thermoresponsive hydrogel precursors are mixed with poly(ethylene glycol)-co-(l-lactic acid) diacrylate (PEG-PLLA-DA) copolymer. The composite DDS is produced by suspending microspheres in hydrogel precursors and polymerisation is initiated by introducing ammonium persulfate (APS) and N,N,N′N′-tetramethylethylenediamine (TEMED).