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. 2020 Jul 22;10:12130. doi: 10.1038/s41598-020-68930-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Representative flow cytometric data (A) and frequencies of apoptotic cells (Annexin V⁺ DAPI⁺) at baseline and week 4 (B). Data are presented as means ± SEMs. Significant differences between PW group (n = 14) and HW group (n = 15) at baseline were determined with the use of an unpaired t test or a Mann–Whitney U test, and those at week 4 were determined with a general linear model adjusting for the value at baseline as a covariate. PW, plain water; HW, H₂-rich water.