Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jul 22;10:12171. doi: 10.1038/s41598-020-68739-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

AD mice exhibit altered protein synthesis and oxidative stress metabolic pathways in the hippocampus. (a) A heat map expressing the normalized peak area concentrations of the top 9 metabolites that are changed between Ctrl and AD mice across age in the HPC. Green indicates greater concentration and red indicates weaker concentration. (b–j) Top 9 metabolites significantly upregulated or downregulated between Ctrl and AD mice in the HPC at different ages. These metabolites are in the aminoacyl-tRNA biosynthesis (l-methionine, isoleucine, tyrosine, arginine); glutathione (glutathione, pyroglutamic acid); and glyoxylate and dicarboxylate (hydroxypyruvic acid, glycolic acid, glyceric acid) metabolic pathways. (n = 3–6 male mice per group). Error bars represent ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001. Ctrl control, AD Alzheimer’s disease.