Table 2.

A summary list of differentially expressed genes (DEGs) in parental and gemcitabine-resistant GemMIA-R3 cells with and without CM03 treatment.

Cell lines	Compound/time	Down	Down strong	Up	Up strong
GemMIA-R3 vs Parental	–	2,138	984	1,640	774
Parental MIA PaCa-2	CM03_6h	2,203	617	2,219	861
	CM03_24h	2,272	770	2,495	1,054
GemMIA-R3	CM03_6h	939	248	647	212
	CM03_24h	2,694	1,187	2,892	1,383

Data from RNA-seq analysis on total RNA extracted from parental and GemMIA-R3 cell lines treated with 400 nM CM03 for 6 h and 24 h, in terms of numbers of DEGs. The DEGs are divided into four subsets: 1. Down Strong = Log₂FC ≤ − 1 and FDR < 0.05; 2. Down = Log₂FC < − 0.5 and FDR < 0.1; 3. Strong Up = Log₂FC ≥ 1 and FDR < 0.05; 4. Up = Log₂FC > 0.5 and FDR < 0.1.