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. 2020 Jul 22;3:392. doi: 10.1038/s42003-020-01118-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Cells exposed to air pollution experienced increased RNA oxidation as compared with clean air controls. RNA oxidation by air pollution is highly selective as 42 transcripts are consistently oxidized. One of these, FDFT1 is highly enriched in 8-oxoG and significantly downregulated at higher oxidative exposures. This event results in reduced FDFT1 protein levels and lower concentrations of intracellular cholesterol. The FDFT1 knockdown promotes cell morphology changes, including transformation of cell shape and reduction of the cytoskeleton organization. These results provide a model linking FDFT1-mediated cholesterol dysregulation and defects in cellular morphology that emerge post exposure to air pollutants.