Table 2.
Association of ERG parameters and CRAO eyes (based on the disease stage), Fellow uninvolved eyes, and Normal Controls.
| Parameters | All CRAO (N = 110) | Incomplete (N = 30) | Subtotal (N = 57) | Total (N = 23) | CRAO subgroups P*†‡ | Incomplete vs Subtotal | Incomplete vs Total | Subtotal vs Total | Fellow eyes (N = 110) | Involved vs Fellow P§ |
Control eyes (N = 30) | Control vs Fellow eyes P# |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dark-adapted 0.01 | ||||||||||||
| B-wave amplitude (μV) |
135.09 ± 91.98 (5.3, 411.3) |
149.17 ± 85.11 (16.9, 344.1) |
125.18 ± 99.99 (13.0, 411.3) |
69.90 ± 56.98 (5.3, 220.0) |
.002† | .394 | .001 | .015 |
199.56 ± 117.10 (13.1, 443.5) |
< .001 |
234.74 ± 98.65 (61.7, 409.7) |
.080 |
| Implicit time (ms) |
90.99 ± 16.48 (35.5, 133.1) |
91.26 ± 15.69 (66.0, 130.0) |
95.40 ± 19.05 (35.5, 138.1) |
97.47 ± 19.32 (42.5, 128.7) |
.370† | .521 | .370 | .866 |
86.16 ± 16.92 (55.5, 135.6) |
< .001 |
80.17 ± 11.12 (60.0, 94.0) |
.111 |
| Dark-adapted 3.0 | ||||||||||||
| A-wave amplitude |
159.49 ± 67.72 (26.2, 334.3) |
160.87 ± 66.54 (52.3, 334.3) |
158.63 ± 63.75 (43.9, 327.3) |
143.76 ± 66.37 (26.2, 281.2) |
.515† | .985 | .549 | .558 |
155.24 ± 72.99 (16.8, 336.7) |
.887 |
150.02 ± 61.05 (81.2, 257.2) |
.767 |
| A-wave implicit time |
24.66 ± 2.83 (18.0, 32.5) |
23.83 ± 2.28 (19.0, 28.0) |
24.75 ± 2.80 (18.0, 32.5) |
25.45 ± 3.22 (19.3, 32.0) |
.066† | .229 | .056 | .148 |
22.62 ± 2.18 (16.3, 31.0) |
< .001 |
21.38 ± 2.76 (16.3, 26.5) |
.094 |
| B-wave amplitude |
244.33 ± 106.95 (17.3, 582.3) |
282.20 ± 103.93 (124.0, 529.0) |
248.26 ± 99.66 (107.0, 582.3) |
161.60 ± 66.96 (17.3, 260.3) |
< .001† | .200 | < .001 | < .001 |
329.10 ± 97.69 (85.7, 531.0) |
< .001 |
359.77 ± 89.67 (221.5, 527.5) |
.198 |
| B-wave implicit time |
50.73 ± 7.05 (34.0, 71.5) |
50.45 ± 4.61 (41.3, 63.0) |
50.95 ± 7.42 (34.0, 65.5) |
50.86 ± 7.04 (38.5, 71.5) |
.937† | .932 | .969 | .998 |
46.48 ± 4.42 (35.5, 59.0) |
< .001 |
44.05 ± 7.05 (29.0, 53.6) |
.159 |
| B/A ratio |
1.59 ± 0.48 (0.64, 2.85) |
1.84 ± 0.45 (1.08, 2.77) |
1.62 ± 0.42 (0.83, 2.85) |
1.16 ± 0.35 (0.64, 2.23) |
< .001‡ | .025 | < .001 | < .001 |
2.52 ± 1.22 (1.20, 7.62) |
< .001 |
2.68 ± 0.99 (1.10, 5.27) |
.602 |
| Dark-adapted 3.0 | ||||||||||||
| Oscillatory potentials |
36.25 ± 21.43 (4.1, 92.3) |
35.49 ± 21.12 (9.2, 92.3) |
34.25 ± 23.14 (4.1, 90.1) |
24.32 ± 15.32 (4.3, 71.5) |
.085‡ | .538 | .053 | .081 |
50.53 ± 28.95 (6.1, 144.1) |
< .001 |
56.97 ± 28.35 (21.1, 118.1) |
.364 |
| Light-adapted 3.0 | ||||||||||||
| A-wave amplitude |
20.81 ± 10.38 (0.8, 54.9) |
24.15 ± 11.01 (6.2, 50.6) |
20.90 ± 10.50 (4.2, 54.9) |
15.28 ± 7.41 (0.8, 32.0) |
.003† | .268 | .002 | .034 |
27.58 ± 12.25 (0.1, 67.7) |
< .001 |
29.56 ± 11.67 (16.0, 64.0) |
.510 |
| A-wave implicit time |
16.31 ± 3.13 (6.0, 27.5) |
15.65 ± 2.76 (6.0, 21.5) |
16.75 ± 3.30 (10.5, 27.5) |
16.89 ± 2.52 (12.0, 23.5) |
.158† | .187 | .233 | .976 |
15.32 ± 1.84 (11.5, 25.5) |
< .001 |
15.01 ± 1.54 (13.0, 18.0) |
.484 |
| B-wave amplitude |
66.45 ± 37.20 (9.6, 176.8) |
77.31 ± 37.94 (23.8, 147.5) |
66.41 ± 35.40 (6.9, 176.8) |
44.74 ± 24.43 (12.0, 93.2) |
< .001† | .275 | < .001 | .013 |
97.93 ± 38.70 (27.4, 225.2) |
< .001 |
100.40 ± 31.97 (50.3, 148.4) |
.791 |
| B-wave implicit time |
33.66 ± 3.27 (26.0, 47.0) |
31.61 ± 2.19 (26.0, 36.0) |
34.02 ± 3.35 (28.5, 47.0) |
34.56 ± 2.67 (29.0, 40.0) |
< .001† | < .001 | < .001 | .687 |
29.82 ± 2.51 (14.5, 41.0) |
< .001 |
29.16 ± 1.51 (25.5, 31.5) |
.271 |
| Photopic negative response |
− 25.76 ± 11.82 (− 57.2, − 4.8) |
− 31.82 ± 13.58 (− 57.2, − 14.2) |
− 17.31 ± 9.72 (− 32.9, − 8.4) |
− 7.64 ± 3.21 (− 11.7, − 4.8) |
< .001† | < .001 | < .001 | < .001 |
− 47.27 ± 18.25 (− 76.4, − 19.2) |
< .001 |
− 40.49 ± 12.41 (− 67.3, − 17.6) |
.725 |
| Light-adapted 3.0 flicker | ||||||||||||
| Amplitude |
47.98 ± 24.69 (6.7, 113.5) |
54.47 ± 24.70 (16.3, 102.3) |
50.81 ± 23.71 (7.8, 113.5) |
33.41 ± 17.79 (6.7, 64.5) |
< .001† | .721 | .001 | .002 |
79.07 ± 27.80 (15.9, 156.3) |
< .001 |
74.44 ± 21.83 (36.5, 109.7) |
.488 |
| Implicit time |
32.45 ± 3.59 (24.5, 42.0) |
30.61 ± 2.82 (25.1, 35.8) |
33.20 ± 3.72 (24.5, 42.0) |
33.46 ± 3.48 (26.1, 40.0) |
< .001† | .001 | .004 | .934 |
28.09 ± 3.02 (23.1, 39.5) |
< .001 |
27.16 ± 3.02 (22.1, 37.5) |
.118 |
P values in boldface indicate statistical significance.
*P-values compared between each CRAO groups.
†One-way ANOVA and student t-test for continuous parametric variables.
‡Kruskal–Wallis test and Mann–Whitney U test for continuous nonparametric variables.
§P-values compared between CRAO involved eyes and fellow eyes. Paired t-test and Wilcoxon signed rank test for continuous parametric and nonparametric paired variables.
#P-values compared to fellow eye. Student t-test for continuous parametric variables and Mann–Whitney U test for continuous nonparametric variables.
ERG electroretinogram, CRAO central retinal artery occlusion.