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Strategies for targeting DUBs upstream of MCL1 in cancer treatment.
| DUB | Strategy | Cancer type |
|---|---|---|
| USP9X | BIX-01294; WP1130 | Hematological malignancies |
| Ku70 | MI-223 | Lung cancer |
| USP13 | Spautin-1 | Ovarian cancer; lung cancer |
| JOSD1 | AAV-shRNA | Gynecological cancer |
| DUB3 | PaTrin-2 | Ovarian cancer |
