Table 2.
Candidate gene expression data.
| Genes | Mean expression levels [95% confidence interval] | Group test | |||||
|---|---|---|---|---|---|---|---|
| Healthy controls (Con) N = 40 | Treatment-responders (Resp) N = 36 | Drug-free (Free) N = 36 | Treatment-resistant (TRD) N = 58 | Statistic | P value | Post hoc | |
| A2M | 1.02 [0.95–1.09] | 1.28 [1.22–1.34] | 1.24 [1.17–1.31] | 1.23 [1.19–1.27] | F = 14.11 | <0.001 | TRD > Con Free > Con Resp > Con |
| CRP | 1.03 [0.96–1.09] | 1.13 [1.07–1.18] | 1.18 [1.08–1.29] | 1.18 [1.13–1.22] | F = 4.54 | 0.004 | TRD > Con Free > Con |
| IL-1beta | 1.07 [1.04–1.10] | 1.16 [1.03–1.28] | 1.22 [1.18–1.26] | 1.32 [1.27–1.37] | F = 12.24 | <0.001 | TRD > Con TRD > Resp Free > Con |
| IL-6 | 1.06 [1.03–1.08] | 1.32 [1.26–1.38] | 1.28 [1.24–1.32] | 1.23 [1.17–1.28] | F = 19.675 | <0.001 | TRD > Con Free > Con Resp > TRD Resp > Con |
| MIF | 1.00 [0.96–1.05] | 1.13 [1.07–1.20] | 1.30 [1.24–1.37] | 1.27 [1.23–1.30] | F = 29.62 | <0.001 | TRD > Con TRD > Resp Free > Con Free > Resp Resp > Con |
| TNF-alpha | 1.06 [1.00–1.11] | 1.24 [1.21–1.27] | 1.30 [1.27–1.33] | 1.32 [1.28–1.35] | F = 35.09 | <0.001 | TRD > Con TRD > Resp Free>Con Resp>Con |
| P2RX7 | 1.03 [0.95–1.12] | 0.79 [0.74–0.84] | 1.27 [1.13–1.40] | 1.25 [1.20–1.30] | F = 29.69 | <0.001 | TRD > Con TRD > Resp Free > Con Free > Resp Con > Resp |
| CCL2 | 1.03 [0.99–1.06] | 0.99 [0.94–1.05] | 1.25 [1.20–1.29] | 1.14 [1.11–1.17] | F = 27.485 | <0.001 | TRD > Con TRD > Resp Free > Con Free > Resp Free > TRD |
| CXCL12 | 1.06 [0.98–1.14] | 0.93 [0.86–1.00] | 1.03 [0.96–1.10] | 1.08 [1.04–1.12] | F = 4.49 | 0.005 | TRD > Resp Con > Resp |
| AQP4 | 1.03 [0.97–1.09] | 1.03 [0.96–1.11] | 1.03 [0.97–1.09] | 1.08 [1.01–1.16] | F = 0.62 | 0.605 | |
| ISG15 | 0.99 [0.91–1.06] | 1.03 [0.95–1.12] | 0.96 [0.88–1.04] | 1.03 [0.95–1.10] | F = 0.64 | 0.59 | |
| STAT1 | 1.06 [1.00–1.11] | 1.08 [1.03–1.14] | 1.23 [1.16–1.30] | 1.19 [1.15–1.23] | F = 9.67 | <0.001 | TRD > Con TRD > Resp Free > Con Free > Resp |
| USP18 | 0.99 [0.91–1.07] | 1.02 [0.93–1.10] | 1.01 [0.95–1.08] | 1.03 [0.98–1.09] | F = 0.245 | 0.865 | |
| FKBP5 | 1.04 [0.97–1.10] | 1.13 [1.08–1.18] | 1.27 [1.23–1.30] | 1.27 [1.25–1.29] | F = 30.31 | <0.001 | TRD > Con TRD > Resp Free > Con Free > Resp Resp > Con |
| GR | 1.05 [1.02–1.08] | 1.01 [0.97–1.05] | 0.83 [0.80–0.87] | 0.87 [0.84–0.90] | F = 40.28 | <0.001 | TRD < Con TRD < Resp Free < Con Free < Resp |
| SGK1 | 1.06 [1.03–1.09] | 1.05 [1.02–1.08] | 1.23 [1.20–1.26] | 1.05 [1.02–1.08] | F = 32.34 | <0.001 | Free > Con Free > Resp Free > TRD |
#Post hoc: ‘one group > /< one group’ means that the first category group has score statistically larger/smaller than the second group.