Table 3.
Binomial regression models output for detecting the best predictors of the binomial (two categories: Resp vs. TRD) study group variable.
| Logistic models | Explanatory variables | Likelihood ratio test | Negelkerke’s pseudo-R2 | |
|---|---|---|---|---|
| Chi2 (degree of freedom) | P value | |||
| Mod. (i) | Trait-anxiety | 23.9 (1) | <0.001 | 0.53 |
| State-anxiety | 0.4 (1) | 0.533 | ||
| CRP | 0.2 (1) | 0.961 | ||
| Neutrophils absolute | 5.9 (1) | 0.015 | ||
| Total white cells | 0.3 (1) | 0.601 | ||
| Total score CTQ | 0.2 (1) | 0.727 | ||
| Mod. (ii) | CXCL12 | 4.0 (1) | 0.038 | 0.89 |
| CCL2 | 4.9 (1) | 0.023 | ||
| IL-1beta | 3.8 (1) | 0.048 | ||
| IL-6 | 3.6 (1) | 0.037 | ||
| GR | 18.4 (1) | <0.001 | ||
| P2RX7 | 11.5 (1) | 0.003 | ||
| SGK1 | 2.2 (1) | 0.125 | ||
| TNF-alpha | 3.7 (1) | 0.042 | ||
| FKBP5 | 4.5 (1) | 0.004 | ||
| A2M | 2.1 (1) | 0.076 | ||
| MIF | 6.1 (1) | 0.018 | ||
| STAT1 | 5.6 (1) | 0.009 | ||
| CRP | 2.8 (1) | 0.086 | ||
| Mod. (iii) # | GR | 5.7 (1) | 0.017 | 0.90 |
| P2RX7 | 14.0 (1) | <0.001 | ||
| TNF-alpha | 4.1 (1) | 0.040 | ||
| Trait-anxiety | 3.9 (1) | 0.051 | ||
| IL-6 | 4.2 (1) | 0.042 | ||
| CCL2 | 3.8 (1) | 0.053 | ||
| IL-1beta | 6.6 (1) | 0.010 | ||
| CXCL12 | 5.7 (1) | 0.031 | ||
| Neutrophils absolute | 1.2 (1) | 0.277 | ||
| FKBP5 | 2.4 (1) | 0.124 | ||
| MIF | 2.5 (1) | 0.113 | ||
| STAT1 | 1.4 (1) | 0.235 | ||
#Explanatory variables of the model (iii) were standardised in order to take into account the different variable ranges.
Mod. (i) considering only (significantly different between group) clinical and blood immune variables; mod. (ii) considering only (significantly different between group) genes variables and mod. (iii) considering both genes and clinical-blood immune variables resulted remained significant in mod. (i) and (ii).