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. 2020 Jul 22;10:12139. doi: 10.1038/s41598-020-69085-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Klf10 deficient mice display enhanced fibrosis priming upon MCDD challenge. (A) Representative images of liver sections sand tained with Picro Sirius red from WT and Klf10^-/- animals fed a CD or MCDD for 4 weeks (ZT3). (B) Quantification of hepatic fibrosis using the clinical fibrosis score (Ishak) (n = 7–12 mice/group). (C) Hepatic gene expression of Tgfβ1, Col1α1and Timp1 in WT and Klf10^-/- mice sacrificed at ZT3 (n = 8–12 mice/group). All the data are expressed as mean ± SEM. The mRNA levels are normalized to B2m and expressed as relative to the CD level ZT3 (n = 12). Statistical significance was tested using the Mann-Whiney test vs the control group (stars) or the indicated groups (dollar symbols), **** p < 0.0001; ** and $$ p < 0.01; $ p < 0.05.