Table 2.
Parameter estimates of final population PK model
| Parameter (unit) | NONMEM estimate | Bootstrap estimates a | |
|---|---|---|---|
| Median | 95% CI | ||
| Fixed effect | |||
| CL/F, L/day | 0.469 | 0.469 | 0.449, 0.489 |
| V1/F, L | 9.22 | 9.20 | 8.88, 9.52 |
| K a, 1/day | 0.456 | 0.456 | 0.383, 0.652 |
| Weight, kg, on CL/F | 0.769 | 0.768 | 0.561, 0.986 |
| Age, years, on CL/F | −0.534 | −0.534 | −0.764, −0.315 |
| Albumin, g/L, on CL/F | −1.17 | −1.18 | −1.61, −0.726 |
| Weight, kg, on V1/F | 0.877 | 0.878 | 0.709, 1.05 |
| Albumin, g/L, on V1/F | −0.610 | −0.609 | −1.01, −0.216 |
| Random effect, % | |||
| Interindividual variability of CL/F | 36.4 | 36.0 | 31.1, 40.9 |
| Interindividual variability of V1/F | 22.5 | 22.3 | 17.0, 27.6 |
| Residual variability | 22.4 | 22.3 | 17.8, 27.5 |
CI, confidence interval; CL/F, apparent clearance; K a, absorption rate constant; NONMEM, nonlinear mixed‐effects modeling; PK, pharmacokinetics; V1/F, apparent volume of distribution.
a
Estimated from nonparametric bootstrap procedure (1,000 successful replicates).