Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jun 19;9(7):374–383. doi: 10.1002/psp4.12506

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 Sanofi U.S. CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of the American Society for Clinical Pharmacology and Therapeutics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

PMC Copyright notice

Comparison of simulation results for a population of 1,000 virtual patients to clinical data. Simulated results for plasma glucosylsphingosine (lyso‐GL)‐1 (a) and spleen volume (c) response to eliglustat overlaid with clinical data from active arm from ENGAGE trial. Simulated results for plasma‐lyso‐GL1 (b) and spleen volume (d) response to eliglustat overlaid with clinical data from the placebo arm and open‐label period of the ENGAGE trial. Mean of virtual population (black solid line), and SD (dashed lines). Mean clinical data from patients are shown as points (white circles: treated arm in ENGAGE trial; gray circles: untreated arm in ENGAGE trial) with SD.