Figure 1.

Structure of the MT model. ANC₀, estimated baseline absolute neutrophil count; ANC_Blood, absolute neutrophil count in circulation; ANC_Marginal, absolute neutrophil counts not in circulation; ANC_T, absolute neutrophil count in tolerance compartment; ANC_{T, transit}, absolute neutrophil count in tolerance transit compartment; C, concentration of IL‐6R inhibitor; EC₅₀, concentration of IL‐6R inhibitor causing half‐maximal effect; E_max, maximal effect of IL‐6R inhibitor on intercompartmental rates; IL‐6R, interleukin‐6 receptor; k, intercompartmental rate; k _in, calculated production rate of neutrophils; k _out, elimination rate of neutrophils based on published estimates of half‐life; k _tol, tolerance rate; LF, link function; MT, margination–tolerance; PK, pharmacokinetic.