Table 1.
Final base MT model with PD effect on margination and demargination rates: population PD parameters and bootstrap CIs
| Parameter value (SE) | Bootstrap median (95% CI) | |
|---|---|---|
| Parameters | ||
| ANC0, ×109/L | 4.53 (0.0986) | 4.53 (4.34–4.68) |
| k, 1/day | 1.60 (0.0915) | 1.59 (1.18–2.22) |
| Emax, unitless | 1.65 (0.0980) | 1.64 (1.36–1.94) |
| EC50, mg/L | 0.797 (0.0812) | 0.769 (0.376–1.72) |
| k tol, 1/day | 0.291 (0.0104) | 0.288 (0.247–0.354) |
| k out, 1/day | 0.877 Fixed | 0.877 Fixed |
| Omegas | ||
| ω, ANC0 | 0.347 (0.0161) | 0.348 (0.319–0.374) |
| ω, Emax | 0.717 (0.0421) | 0.723 (0.625–0.809) |
| SD of residual error | ||
| σexponential | 0.253 (0.00156) | 0.253 (0.245–0.264) |
| Log‐likelihood estimation | ||
| −2 log‐likelihood | 12,617.692 | – |
| BIC | 12,693.581 | – |
ANC, absolute neutrophil count; ANC0, estimated baseline ANC; BIC, Bayesian information criterion; CI, confidence interval; EC50, concentration of drug causing half‐maximal effect; Emax, maximum drug‐induced effect; k, intercompartmental rate; k out, neutrophil elimination rate; k tol, tolerance rate; MT, margination–tolerance; ω, between‐subject SD in parameters; PD, pharmacodynamic; SE, standard error; σ, SD.