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. 2020 Jul 23;51:93. doi: 10.1186/s13567-020-00818-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Mouse serum anti-fimbriae IgG antibody titers (log10) from SC immunized with FaeG–FedF–FanC–FasA–Fim41a MEFA protein. A Titration of anti-FaeG, FedF, FanC, FasA, and Fim41a IgG antibodies in serum samples of the FaeG–FedF–FanC–FasA–Fim41a MEFA protein immunized mice (filled circle) and control mice (open circle). Each circle represents the IgG titer from a single mouse. Bars indicate the mean titers of the group specific to each fimbria. Antibody titers are presented as log₁₀. B Comparison of the specific anti-fimbriae antibody titers between the co-administration group and FaeG–FedF–FanC–FasA–Fim41a MEFA group. *Statistically significant difference when compared to the co-administration group (P < 0.05), **Statistically significant difference when compared to the co-administration group (P < 0.01).