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The role of host eIF2α in viral infection. Different viruses can stimulate specific eIF2α kinases, or the same virus can stimulate different eIF2α kinases, such as PRRSV, HCV, and EV71, which can activate PKR and PERK. eIF2α phosphorylation can affect host cell translation efficiency, SG formation, the cell cycle, and autophagy or apoptosis, thus facilitating viral infection
