Table 1.
Strategies of some viruses for inhibiting SG formation. Viruses have evolved the following strategies to regulate SGs and thus promote their survival
| Virus | Viral protein | Strategies for resisting SG formation | Reference |
|---|---|---|---|
| Rotavirus | Changes the cellular localization of TIA-1 and PABP | [5] | |
| MNV | Recruits G3BP1 to the viral replication complex | [84] | |
| ZIKV | Alters the cellular localization of HuR | [109] | |
| EV71 | 2A | Cleaves eIF4GI | [110] |
| EV71 | 3C | Cleaves G3BP1 | [111] |
| PV | 3C | Cleaves G3BP1 | [112] |
| FMDV | L | Cleaves G3BP1 and G3BP2 | [113] |
| EMCV | 3C | Cleaves G3BP1 | [58] |
| Picornavirus | L or 2A | Interferes with the eIF4GI-G3BP1 interaction | [114] |
| HPIV3 | Hides viral RNA | [115] | |
| HIV-1 | Inhibits PKR and eIF2α phosphorylation | [116, 117] |