Table 1. Informatics functional components that support the FAIR (Findable (F), Accessible (A), Interoperable (I), and Reusable (R)) principles.

The FAIR principles listed in the table are from the cited reference 44.

	BRICS Functional Components
FAIR Principles	GUID	Data Dictionary	Data Repository	ProFoRMs	Query Tool	MetaStudy
Findable
Data are assigned a globally unique and eternally persistent identifier	x	x	x			x
Data are described with rich metadata		x	x	x	x	x
Metadata clearly and explicitly include the identifier of the data it describes			x			x
(Meta) data are registered or indexed in a searchable resource		x	x
Accessible
(Meta) data are retrievable by their identifier using a standardized communications protocol		x
The protocol is open, free, and universally implementable		x
The protocol allows for an authentication and authorization procedure, where necessary	x	x	x	x	x	x
Metadata are accessible, even when the data are no longer available		x
Interoper-able
(Meta) data use a formal, accessible, shared, and broadly applicable language for knowledge representation		x	x
(Meta) data use vocabularies that follow FAIR principles		x	x	x
(Meta) data include qualified references to other (meta) data		x			x
Reusable
(Meta) data have a plurality of accurate and relevant attributes		x	x		x	x
(Meta) data are released with a clear and accessible data usage license		x	x			x
(Meta) data are associated with their provenance		x	x			x
(Meta) data meet domain-relevant community standards		x	x