Table 2.
Rates of positive BRCA1 and BRCA2 mutation across different indications.
| Variable | Total | Positive mutations | ||||
|---|---|---|---|---|---|---|
| BRCA1 | BRCA2 | BRCA1 and BRCA2 | P value∗ | |||
| Age at diagnosis (years) | ≤40 | 333 | 15 (4.5%) | 29 (8.7%) | 44 (13.2%) | 0.530 |
| >40 | 184 | 9 (4.9%) | 19 (10.3%) | 28 (15.2%) | ||
|
| ||||||
| Age ≤ 50 years with one or more close relatives with breast cancer at any age | Yes | 242 | 8 (3.3%) | 32 (13.2%) | 40 (16.5%) | 0.1 |
| No | 275 | 16 (5.8%) | 16 (5.8%) | 32 (11.6%) | ||
|
| ||||||
| Age ≤ 60 with triple-negative disease | Yes | 57 | 16 (28.1%) | 4 (7.0%) | 19 (35.1%) | <0.001 |
| No | 460 | 8 (1.7%) | 44 (9.6%) | 53 (11.5%) | ||
|
| ||||||
| Any age with at least 2 breast cancer primaries | Yes | 57 | 4 (7.0%) | 4 (7.0%) | 8 (14.0%) | 0.98 |
| No | 460 | 20 (4.3%) | 44 (9.6%) | 64 (13.9%) | ||
|
| ||||||
| Any age with 2 or more close relatives with breast cancer | Yes | 115 | 7 (6.1%) | 21 (18.3%) | 28 (24.3%) | <0.001 |
| No | 402 | 17 (4.2%) | 27 (6.7%) | 44 (10.9%) | ||
|
| ||||||
| Any age with one or more close relatives with invasive ovarian cancer diagnosed at any age | Yes | 19 | 2 (10.5%) | 4 (21.1%) | 6 (31.6%) | 0.023 |
| No | 498 | 22 (4.4%) | 44 (8.8%) | 66 (13.3%) | ||
|
| ||||||
| All patients | 517 | 24 (4.6%) | 48 (9.3%) | 72 (13.9%) | ||
∗ P value comparing risk factor categories.