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Preferential binding of compound 6 to the inactive conformation of ChTS. ChTS activity was measured at varying concentrations of 6. The plot in (A) denotes dose-dependent inhibition when 6 was mixed with ChTS in the absence of dUMP (inactive conformation). The plot in (B) denotes dose-dependent inhibition when 6 was mixed with ChTS in the presence of dUMP (active conformation).
