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. 2020 Jul 22;156(10):1–8. doi: 10.1001/jamadermatol.2020.2158

Table 3. Pooled Results of Subgroup Analyses of Bullous Pemphigoid in Initiation of Second-generation Sulfonylurea and DPP-4 Inhibitor Use.

Characteristic Sulfonylurea DPP-4 inhibitor HR (95% CI)
No. of patients No. of events Person-years IR per 1000 person-years No. of patients No. of events Person-years IR per 1000 person-years
Age, y
≥65 423 862 155 316 764 0.49 423 862 229 290 423 0.79 1.62 (1.32-1.99)
<65 399 989 26 269 975 0.10 399 989 26 286 052 0.09 0.94 (0.55-1.62)
Sex
Male 406 720 99 303 820 0.33 406 720 122 295 157 0.41 1.38 (1.06-1.79)
Female 424 850 96 290 818 0.33 424 850 124 287 548 0.41 1.34 (1.03-1.75)
Racea
White 208 960 86 158 099 0.54 208 960 128 138 181 0.93 1.70 (1.30-2.24)
Nonwhite 68 499 28 41 988 0.67 68 499 22 43 411 0.51 0.77 (0.44-1.34)
Individual drugs
Sitagliptin phosphate 654 923 136 464 464 0.29 654 923 156 448 105 0.35 1.15 (0.91-1.45)
Saxagliptin hydrochloride 123 216 20 93 256 0.21 123 216 25 86 928 0.29 0.97 (0.56-1.67)
Linagliptin 119 316 42 76 012 0.55 119 316 85 71 103 1.20 1.68 (1.16-2.43)

Abbreviations: DPP-4, dipeptidyl peptidase-4; HR, hazard ratio; IR, incidence rate.

a

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