Table 3. Pooled Results of Subgroup Analyses of Bullous Pemphigoid in Initiation of Second-generation Sulfonylurea and DPP-4 Inhibitor Use.
Characteristic | Sulfonylurea | DPP-4 inhibitor | HR (95% CI) | ||||||
---|---|---|---|---|---|---|---|---|---|
No. of patients | No. of events | Person-years | IR per 1000 person-years | No. of patients | No. of events | Person-years | IR per 1000 person-years | ||
Age, y | |||||||||
≥65 | 423 862 | 155 | 316 764 | 0.49 | 423 862 | 229 | 290 423 | 0.79 | 1.62 (1.32-1.99) |
<65 | 399 989 | 26 | 269 975 | 0.10 | 399 989 | 26 | 286 052 | 0.09 | 0.94 (0.55-1.62) |
Sex | |||||||||
Male | 406 720 | 99 | 303 820 | 0.33 | 406 720 | 122 | 295 157 | 0.41 | 1.38 (1.06-1.79) |
Female | 424 850 | 96 | 290 818 | 0.33 | 424 850 | 124 | 287 548 | 0.41 | 1.34 (1.03-1.75) |
Racea | |||||||||
White | 208 960 | 86 | 158 099 | 0.54 | 208 960 | 128 | 138 181 | 0.93 | 1.70 (1.30-2.24) |
Nonwhite | 68 499 | 28 | 41 988 | 0.67 | 68 499 | 22 | 43 411 | 0.51 | 0.77 (0.44-1.34) |
Individual drugs | |||||||||
Sitagliptin phosphate | 654 923 | 136 | 464 464 | 0.29 | 654 923 | 156 | 448 105 | 0.35 | 1.15 (0.91-1.45) |
Saxagliptin hydrochloride | 123 216 | 20 | 93 256 | 0.21 | 123 216 | 25 | 86 928 | 0.29 | 0.97 (0.56-1.67) |
Linagliptin | 119 316 | 42 | 76 012 | 0.55 | 119 316 | 85 | 71 103 | 1.20 | 1.68 (1.16-2.43) |
Abbreviations: DPP-4, dipeptidyl peptidase-4; HR, hazard ratio; IR, incidence rate.
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