Figure 3. Building 3D Human Tumor Atlases.
HTAN centers will measure data modalities at multiple scales of resolution, from molecular to ultrastructural to cellular to histological to anatomical (when possible), and will collect relevant clinical information from patients with tumors under study. These modalities will be used for profiling samples according to the capabilities of each HTAN center. Most centers will use both molecular and spatial profiling methods to generate data. Data that pass HTAN-defined basic processing and quality control will be utilized for interrogating cell-type composition, cell-cell interactions, and spatial structures (left panels). Atlases will then be constructed through the integration of these data modalities measured across time (right panel).