Table 3.

Multivariate Cox proportional hazard models for recurrence-free survival

Variables in model		Hazard ratio	95% confidence interval	p
pN stagea (pN1 vs pN0)		1.99	0.79–5.03	0.144
Ki67 DIA hot spot APP24 scoring (≥ 20% vs < 20%)		13.80	1.83–104.05	0.011*
pN stage (pN0 vs pN1)		1.54	0.61–3.90	0.361
Ki67 DIA global scoring (≥ 20% vs < 20%)		3.53	1.31–9.54	0.013*
pN stage (pN0 vs pN1)		1.44	0.57–3.65	0.438
Ki67 manual hot spot scoring (≥ 20% vs < 20%)		3.31	1.08–10.11	0.036*

DIA digital image analysis

*p significant at a < 0.05 level

^aPathologic N stage for regional lymph nodes according to AJCC Breast Cancer Staging 7th Edition (TNM 7)