Table 4.
Multivariate Cox proportional hazard models for overall survival
| Variables in model | Hazard ratio | 95% confidence interval | p |
|---|---|---|---|
| Grade (1 ref) | – | – | – |
| Grade 2 | 0.92 | 0.08–10.80 | 0.949 |
| Grade 3 | 10.55 | 0.39–287.98 | 0.163 |
| Mitotic score (1 ref) | – | – | – |
| Mitotic score 2 | 0.42 | 0.04–4.85 | 0.487 |
| Mitotic score 3 | 0.21 | 0.01–3.64 | 0.284 |
| pN stagea (pN1 vs pN0) | 2.28 | 0.73–7.14 | 0.158 |
| Ki67 DIA hot spot APP24 scoring (≥ 20% vs < 20%) | 2.93 | 0.50–17.35 | 0.236 |
| Grade (1 ref) | – | – | – |
| Grade 2 | 1.05 | 0.09–11.62 | 0.971 |
| Grade 3 | 6.25 | 0.23–171.59 | 0.278 |
| Mitotic score (1 ref) | – | – | – |
| Mitotic score 2 | 0.30 | 0.03–3.70 | 0.348 |
| Mitotic score 3 | 0.19 | 0.01–3.40 | 0.261 |
| pN stagea (pN1 vs pN0) | 1.87 | 0.61–5.75 | 0.277 |
| Ki67 DIA global scoring (≥ 20% vs < 20%) | 7.11 | 1.09–46.46 | 0.040* |
| Grade (1 ref) | – | – | – |
| Grade 2 | 1.09 | 0.10–12.06 | 0.944 |
| Grade 3 | 13.32 | 0.51–348.73 | 0.120 |
| Mitotic score (1 ref) | – | – | – |
| Mitotic score 2 | 0.70 | 0.06–8.23 | 0.778 |
| Mitotic score 3 | 0.50 | 0.03–9.40 | 0.645 |
| pN stagea (pN1 vs pN0) | 1.60 | 0.51–5.01 | 0.423 |
| Ki67 manual hot spot scoring (≥ 20% vs < 20%) | 0.72 | 0.20–2.65 | 0.620 |
DIA digital image analysis
*p significant at a < 0.05 level
aPathologic N stage for regional lymph nodes according to AJCC Breast Cancer Staging 7th Edition (TNM 7)