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. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: Am J Cardiol. 2020 Apr 7;126:94–102. doi: 10.1016/j.amjcard.2020.03.043

Table 4:

Major Societal Guidelines on Lp(a) Screening

Class Level of
Evidence
2018 ACC/AHA
Cholesterol Guidelines
Screening Lp(a) in intermediate risk patients who are considering statin therapy IIa B-NR*
2019 European Society of Cardiology
Cholesterol Guidelines
One time screening of Lp(a) in general to identify those at higher overall risk IIa C
2019 National Lipid Association72
First degree relatives with premature ASCVD (men <55; women <65 years of age) IIa C-LD**
A personal history of premature ASCVD IIa C-LD**
Suspected FH or primary severe hypercholesterolemia (LDL-C ≥ 190 mg/dL) IIa B-NR*
To aid in risk discussion for intermediate risk patients ages 40-75 IIa B-NR*
Identify cause of less than expected LDL-C lowering IIb C-LD**
Use as cascade screening in family members with severe hypercholesterolemia IIb C-LD**
Identify risk of progressive aortic stenosis IIb C-LD**
*

Nonrandomized data

**

Limited data