Table 3: Multivariate Model.
Association of risk of death or non-relapsed mortality when controlling for change in CMV serostatus, and toxicities that were significant based on a univariate analysis. Separate multivariate models were fit to each toxicity.
| Risk of death* | Risk of NRM* | |||||
|---|---|---|---|---|---|---|
| HR (95% CI ) | P-value | HR (95% CI ) | P-value | |||
| Cardiovascular | 1.2 (0.72 to 2.02) | 0.48 | 2.29 (1.15 to 4.57) | 0.018 | ||
| Age | 1.03 (1 to 1.05) | 0.032 | 1.02 (0.98 to 1.05) | 0.339 | ||
| ptCMV | 1.66 (0.99 to 2.76) | 0.053 | 1.86 (0.91 to 3.82) | 0.089 | ||
| HCT-CI | 0 | (reference) | (reference) | |||
| 1–2 | 1.41 (0.64 to 3.11) | 0.391 | 1.21 (0.36 to 4.04) | 0.754 | ||
| >=3 | 2.21 (1.06 to 4.61) | 0.035 | 2.81 (0.97 to 8.18) | 0.058 | ||
| Hepatic | 2.72 (1.07 to 6.89) | 0.035 | ||||
| Age | 1.03 (1.01 to 1.06) | 0.015 | ||||
| ptCMV | 1.54 (0.92 to 2.57) | 0.098 | ||||
| HCT-CI | 0 | (reference) | ||||
| 1–2 | 1.43 (0.65 to 3.15) | 0.369 | ||||
| >=3 | 2.23 (1.07 to 4.63) | 0.032 | ||||
| Hematologic | 2.65 (1.6 to 4.39) | <0.001 | 7.49 (3.34 to 16.79) | <0.001 | ||
| Age | 1.03 (1.01 to 1.06) | 0.011 | 1.03 (1 to 1.06) | 0.075 | ||
| ptCMV | 1.45 (0.87 to 2.42) | 0.158 | 1.42 (0.69 to 2.94) | 0.343 | ||
| HCT-CI | 0 | (reference) | (reference) | |||
| 1–2 | 1.68 (0.76 to 3.7) | 0.201 | 1.67 (0.5 to 5.56) | 0.406 | ||
| >=3 | 2.43 (1.17 to 5.06) | 0.017 | 3.53 (1.22 to 10.25) | 0.02 | ||
| Neurologic | 2.21 (1.24 to 3.94) | 0.007 | 5.79 (2.86 to 11.74) | <0.001 | ||
| Age | 1.03 (1 to 1.05) | 0.045 | 1.01 (0.98 to 1.05) | 0.486 | ||
| ptCMV | 1.63 (0.98 to 2.72) | 0.06 | 1.74 (0.85 to 3.58) | 0.131 | ||
| HCT-CI | 0 | (reference) | (reference) | |||
| 1–2 | 1.29 (0.58 to 2.86) | 0.526 | 0.93 (0.27 to 3.14) | 0.902 | ||
| >=3 | 2.04 (0.97 to 4.26) | 0.059 | 2.19 (0.74 to 6.5) | 0.158 | ||
| Pulmonary | 3.11 (1.87 to 5.2) | <0.001 | 9.01 (4.53 to 17.91) | <0.001 | ||
| Age | 1.02 (1 to 1.05) | 0.048 | 1.02 (0.99 to 1.05) | 0.281 | ||
| ptCMV | 1.78 (1.07 to 2.98) | 0.028 | 2.22 (1.07 to 4.61) | 0.032 | ||
| HCT-CI | 0 | (reference) | (reference) | |||
| 1–2 | 1.32 (0.6 to 2.91) | 0.492 | 1.01 (0.3 to 3.4) | 0.982 | ||
| >=3 | 2.1 (1.01 to 4.38) | 0.047 | 2.53 (0.87 to 7.4) | 0.09 | ||
| Renal | 4.07 (2.15 to 7.72) | <0.001 | 9.88 (4.54 to 21.52) | <0.001 | ||
| Age | 1.02 (1 to 1.05) | 0.07 | 1.01 (0.97 to 1.04) | 0.65 | ||
| ptCMV | 1.88 (1.12 to 3.15) | 0.017 | 2.59 (1.24 to 5.41) | 0.011 | ||
| HCT-CI | 0 | (reference) | (reference) | |||
| 1–2 | 1.36 (0.62 to 2.99) | 0.447 | 1.17 (0.35 to 3.89) | 0.803 | ||
| >=3 | 1.74 (0.82 to 3.72) | 0.149 | 1.94 (0.64 to 5.89) | 0.241 | ||
*
within the first year. HCT-CI, HCT-CI, hematopoietic cell transplantation-comorbidity index