Fig. 4.

Effect of MDP treatment on key proteins involved in synaptic functions, Aβ vascular clearance, and cerebrovascular monocyte adhesion. a, b Immunoblot analysis of synaptophysin and PSD95 protein levels, respectively, in the cortex and hippocampus of APP mice treated with vehicle and MDP, n = 10 mice per group. Data are expressed as the means ± SEM; ^*P < or = 0.03. c, d Immunoblot analysis of LRP1 and MCP-1 protein levels respectively in the cortex and hippocampus of APP mice treated with vehicle and MDP, n = 10 mice per group. Data are expressed as the means ± SEM; ^*P < or = 0.03. e, f Immunoblot analysis of VCAM and ICAM-1 protein levels, respectively, in the cortex and hippocampus of APP mice treated with vehicle and MDP, n = 10 mice per group. Data are expressed as the means ± SEM; ^****P < or = 0.0001