Fig. 3.

Biological analysis with Clue Go Cytoscape plugin of statistically significant, differentially expressed genes. a Upregulated genes with associated biological functions as identified through mean and normalization (Fig. 2b) of each younger vs. older patient comparison (n = 10) in a network and pie chart representation. b Downregulated genes with associated biological functions as identified through mean and normalization of each younger vs. older patient comparison (n = 10) in a network and pie chart representation. Genes that enrich each category with statistical significance p value < 0.05 appear connected to each GO_Biological Process node. Thickness of each edge represents statistical significance. Image was generated and adapted with Cytoscape plugin Clue GO V.2.5.4 [31]