Fig. 4.

FSH and AMH interactome within feature, differentially expressed gene list. a Venn diagram (Venny 2.1.0) highlighting commonalities between AMH regulated genes vs. FSH regulated genes. Gene Card Database (https://www.genecards.org) was employed to identify genetic targets of both FSH (Hit word: Follicle Stimulating Hormone Subunit Beta. FSHB) and AMH. Target gene lists for each hormone where compared with the RNA-seq feature (target) list to identify potential areas of overlap. a One common element was identified between the “target gene list” and the “FSH interactome”: PTHLH. Five common elements (representing 1.7% of the target gene list) were identified between the “target gene list” and the “AMH interactome” which are as follows: SMAD1, SMAD4, SMAD5, ALK1, LEF1. Lastly, three common elements were identified between the “AMH interactome” and the “FSH interactome”: ACVR2A, BMPR1B, SKIL.b Focussed heat map analysis of Venn diagram sourced, overlapping genes