Fig. 1.

Expression pattern of hsa_circ_0000735 in DTX-resistant PCa tissues and cells. a The schematic exhibited the circularizing of P2RX1 exons 2-8 into the form of hsa_circ_0000735 by head-to-tail. The splice junction of hsa_circ_0000735 was verified through RT-PCR and Sanger sequencing. b The expression levels of hsa_circ_0000735 in 23 DTX-sensitive PCa tissues, 27 DTX-resistant PCa tissues, and 50 adjacent normal tissues were examined through qRT-PCR. c, d The expression levels of hsa_circ_0000735 in PC-3, DU145, PC-3/DTX, DU145/DTX, and RWPE-1 cells were evaluated by qRT-PCR. e Kaplan–Meier survival curves of overall survival for patients with high or low hsa_circ_0000735 expression after DTX treatment. The median value of hsa_circ_0000735 expression was deemed as the cutoff value. **P < 0.01 and ***P < 0.001