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. 2020 Jul 22;20:334. doi: 10.1186/s12935-020-01421-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Influence of hsa_circ_0000735 knockdown on the sensitivity of DTX-resistant PCa cells to DTX. a The illustration exhibited siRNAs (si-circ-1 and si-circ-2) that target the junction of hsa_circ_0000735. b, c QRT-PCR results for P2RX1 mRNA and hsa_circ_0000735 in PC-3/DTX and DU145/DTX cells transfected with si-NC, si-circ-1, or si-circ-2. d, e The viability of PC-3/DTX and DU145/DTX cells transfected with si-NC or si-circ-1 in the presence of DTX at the different concentrations (5, 10, 20, 40, 80, or 160 nM) for 48 h was determined through CCK-8 assay. f–k The viability, colony formation, cell cycle progression, and apoptosis of PC-3/DTX and DU145/DTX cells transfected with si-NC or si-circ-1 under DTX (10 nM) treatment were assessed with CCK-8, cell colony formation, or flow cytometry assays. l, m The levels of MDR1, cyclinD1, and bcl-2 in PC-3/DTX and DU145/DTX cells transfected with si-NC or si-circ-1 under DTX (10 nM) treatment were assessed via western blotting. *P < 0.05 and ***P < 0.001