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. 2016 Jul 1;129(13):2573–2585. doi: 10.1242/jcs.186767

Fig. 1.

Fig. 1.

HOXD10 is a downstream mediator of VEGFR-3 induced gene expression in LECs. Transcription factor (TF) activity analysis using oPOSSUM3 on VEGF-C156S-stimulated LECs was performed based on the presence of TFBS in the promoters of differentially expressed transcripts. (A) Schematic overview of the analysis workflow and HOXD10 TFBS derived from JASPAR (jaspar.genereg.net). Data shown represent the 15-min (B), 30-min (C), 80-min (D), 300-min (E) and 360-min time points (F) after VEGF-C156S stimulation. HOXD10 TFBS overrepresentation is indicated by the Z-score (left panels), and overrepresentation of promoters with at least one HOXD10 TFBS is indicated by the Fisher score (right panels). The horizontal line indicates the significance cutoff (mean+1.5×s.d.). Transcription factors are plotted on the x-axis according to the guanine and cytosine (GC) content of their corresponding transcription-factor-binding profiles from JASPAR.