Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jul 22;17:47. doi: 10.1186/s12987-020-00209-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 4 — The abundance of RMT receptor and transporter gene transcripts in human (a) and mouse (b) brain microvessels (BMV). BMVs were isolated as described in Materials and Methods and subjected to RNASeq analyses. Data are shown as normalized read counts (Mean ± SD from three biological replicates). Statistical analyses was performed using one-way ANOVA, followed by Tukey’s multiple comparisons test and p < 0.05 was considered significant. For human BMV (a), the level of SLC2A1/GLUT1 is significantly higher than those of IGF2R, LRP8, and LEPR (p < 0.05). The level of SLC3A2/CD98hc is significantly higher than those of LDLR, LRP8, IGFR, IGF2R and LEPR (p < 0.05). The level of LRP1 is significantly higher than those of TFRC, LDLR, IGF1R and LEPR (p < 0.05) and LRP8 and IGF2R (p < 0.01). For mouse BMV (b), the level of SLC2A1/GLUT1 is significantly higher than those of TFRC, INSR, IGF1R, IGF2R, LDLR, LRP8, CDC50A, and LEPR (p < 0.0001), and LRP1 (p < 0.001). The level of SLC3A2/CD98hc is significantly higher than those of TFRC and INSR (p < 0.05), LDLR, IGF2R and LEPR (p < 0.0001). The level of LRP1 is significantly higher than those of TFRC, INSR, IGF2R, LDLR, LRP8 and LEPR (p < 0.0001) and CDC50A (p < 0.001). The level of IGF1R is significantly higher than those of TFRC and INSR (p < 0.01), CDC50A (p < 0.05), IGF2R and LEPR (p < 0.0001). The level of TFRC is significantly higher than those of IGF2R (p < 0.05) and LEPR (p < 0.01). The level of LRP8 is significantly higher than those of IGF2R (p < 0.05) and LEPR (p < 0.01). The level of CDC50A is significantly higher than those of IGF2R and LEPR (p < 0.01)