Table 2.
Clinical outcome of IVF-PGT-M in carriers of the FRAX premutation and the FRAX mutation
| FRAX premutation cycles | FRAX full mutation cycles | p value | ||
|---|---|---|---|---|
| (n = 56) | (n = 30) | |||
| Protocol (%) |
Long Agonist Antagonist Short agonist |
34 (60.7) 21 (37.5) 1 (1.9) |
15 (50) 15 (50) |
- |
| Stimulation outcome |
Satisfying ovarian response (%) Cycle cancellation (%) |
48 (85.7%) 8 (14.5%) |
25 (83.3%) 5 (16.7%) |
0.7703 |
| Mean ovarian stimulation duration (days) (SD) | 10.1 (2.1) | 9.7 (1.1) | 0.2364 | |
| Mean total dose of FSH/cycle (IU)(SD) | 2740 (857) | 1944 (857) | 0.0069 | |
| Mean estradiol peak (pg/mL) (SD) | 1996 (1242) | 2529 (1595) | 0.1065 | |
| Mean number of retrieved oocytes (SD) | 10.9 (4.9) | 10.6 (5.1) | 0.765 | |
| Mean number of metaphase II oocytes (SD) | 7.1 (5.0) | 6.6 (4.2) | 0.871 | |
| Mean number of day 3 embryos (SD) | 5.6 (4.1) | 4.9 (3.5) | 0.554 | |
| Mean number of embryos to transfer after genetic analysis (SD) | 1.7 (1.1) | 2 (1.5) | 0.4253 | |
| Mean number of transferred embryos after genetic analysis (SD) | 1.5 (0.5) | 1.6 (0.5) | 0.5020 | |
| Pregnancy rate/started cycle (%) | 13/56 (23.2%) | 2/30 (6.7%) | 0.0787 | |
| Pregnancy rate/oocyte retrieval (%) | 13/48 (27.1%) | 2/25 (8.0%) | 0.0851 | |
| Pregnancy rate/embryo transfer (%) | 13/35 (37.1%) | 2/15 (13.3%) | 0.1076 | |