Table 2. Simplified structures of proposed new antiviral drug oriented to coronavirus SARS-CoV-2.
| Compound | Antiviral drug | Linker | Triterpene | Alkylamine moiety |
|---|---|---|---|---|
|
1a 1b |
Favipiravir | Hydroxyimino group or dimethylsuccinate moiety | Oleanolamide | 1-(diethylamino) pentan-4-yl |
|
2a 2b |
Favipiravir | Hydroxyimino group or dimethylsuccinate moiety | Oleanolamide | N-ethyl-N-hydroxyethyl-(1-aminopentan)-4-yl |
|
3a 3b |
Favipiravir | Hydroxyimino group or dimethylsuccinate moiety | Oleanolamide | 1-morpholinpentan-4-yl |
| 4 | Remdesivir | Acetate moiety | Oleanolamide | 1-(diethylamino) pentan-4-yl |
| 5 | Remdesivir | Acetate moiety | Oleanolamide | N-ethyl-N-hydroxyethyl-(1-aminopentan)-4-yl |
| 6 | Remdesivir | Acetate moiety | Oleanolamide | 1-morpholinpentan-4-yl |
| 7 | Galidesivir | Dimethylsuccinate moiety | Oleanolamide | 1-(diethylamino) pentan-4-yl |
| 8 | Galidesivir | Dimethylsuccinate moiety | Oleanolamide | N-ethyl-N-hydroxyethyl-(1-aminopentan)-4-yl |
| 9 | Galidesivir | Dimethylsuccinate moiety | Oleanolamide | 1-morpholinpentan-4-yl |
|
10a 10b |
Tilorone (oxime) | Acetate group or dimethylsuccinate moiety | Oleanolamide | 1-(diethylamino) pentan-4-yl |
|
11a 11b |
Tilorone (oxime) | Acetate group or dimethylsuccinate moiety | Oleanolamide | N-ethyl-N-hydroxyethyl-(1-aminopentan)-4-yl |
|
12a 12b |
Tilorone (oxime) | Acetate group or dimethylsuccinate moiety | Oleanolamide | 1-morpholinpentan-4-yl |